
Everything You Need to Know About the Endocannabinoid System
Have you ever wondered why smoking weed makes you feel different than your friends? You can thank the unique workings of the endocannabinoid system for that.
Although it was discovered in the 1990s by scientists, the endocannabinoid has always been a bit of a mystery when compared to other body systems.
In this guide, we’ll discuss everything you need to know about the endocannabinoid system, including how it works, what body functions it controls, and how cannabis affects it.
What is the Endocannabinoid System?
The endocannabinoid system (ECS) is a metabolic body system composed of chemical signals and receptors that act as a bridge between the body and mind.
It performs complex actions within the nervous system, the immune system, and all of the body’s organs. The body cannot be in a state of complete and total health if the endocannabinoid system is not functioning properly.
The endocannabinoid system is activated by cannabinoids that are either created naturally within the body (known as endocannabinoids) as well as the ones that are found in cannabis (known as phytocannabinoids).
Here’s a tip for remembering the difference between these compounds: “endo” refers to internal compounds while “phyto” refers to plant compounds.
Endocannabinoid receptors are located all over the body. The brain is primarily composed of CB1 receptors that control the activity levels of neurotransmitters, which influence things like body temperature, appetite, concentration levels, mood, and hunger.
CB2 receptors are primarily located within our immune tissues. Their job is to control inflammation and regulate the immune response.
Because the majority of our immune cells reside in the gut, CB2 receptors are also responsible for influencing intestinal inflammation, contractions, regularity, and pain or other symptoms associated with IBD.
How Does The Endocannabinoid System Work?
To understand how the endocannabinoid system works, let’s take a look at an example of someone who has fallen and is in pain. When you fall and hit the ground, you feel immediate pain.
However, after you fall, the nervous system sends out enzymes that interrupt the pain signal so that you stop feeling pain a few minutes after falling. These enzymes work by creating endocannabinoids that help regulate the pain response.
The two main types of endocannabinoids produced are:
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Anandamide: this compound is known as the ‘bliss molecule’ because it regulates the reward response, mood, and emotions. Low levels are linked to depression, anxiety, and other mood disorders.
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2-Arachidonoylglycerol (also known as 2-AG): this compound is primarily responsible for regulating inflammation. It plays a large role in boosting immune health, controlling the pain response, and regulating mood, memory, and sleep.
The endocannabinoid system is in charge of regulating many responses as well as influencing the development (or prevention) of some diseases.
Essentially, it’s in charge of maintaining homeostasis within the body, meaning that it oversees a variety of processes to ensure everything is working in harmony.
Nervous system support
The autonomic nervous system has two main parts: the sympathetic and the parasympathetic systems. The sympathetic nervous system is what controls the “flight or fight” response while the parasympathetic system functions within the digestion and sleep aspects of our health.
The entire automatic system helps regulate digestion, heart rate, breathing, blood pressure, body heat, and pupil dilation.
Research shows that when there are problems within the CB1 receptors, it causes problems with learning, memory, pain, addiction, reward, neuroinflammation, degeneration, metabolism, food intake, bone mass, and more.
Problems with CB2 receptors have been linked to chronic pain, alcohol and nicotine addiction, stress, autoimmune conditions, and more.
Sleep Cycle
Sleep cycles are regulated by the body’s internal clock, which is also known as circadian rhythms. Research shows that activation of the CB1 receptors may help promote sleep.
Immune response
The endocannabinoid system has both an inhibitory and a stimulatory effect on the immune system. This is ideal for those with autoimmune conditions because it helps tame the overactive response that is responsible for activating the disease.
Research shows that activating the endocannabinoid system may help relieve symptoms of multiple sclerosis, osteoarthritis, asthma, HIV, and even cancer.
Pain signals
The endocannabinoid system helps intercept pain signals that the body sends to the brain, which can help reduce symptoms of chronic pain. It’s also responsible for regulating inflammatory responses that may contribute to pain.
Body temperature
With the help of the sympathetic nervous system, the body maintains a normal core temperature that responds to factors such as heart rate and blood pressure, allowing the body to maintain internal balance.
Sometimes, your core temperature increases when you are fighting an infection. Cannabinoids – such as THC – have been shown to reduce body temperature when you are sick.
How Does Cannabis Affect the Endocannabinoid System?
Although the body naturally produces cannabinoids, using cannabis is an excellent way to provide the endocannabinoid system with the compounds it needs to stay properly regulated.
Considering that there are thousands of cannabis strains and each contains its own unique cannabinoid profile, it’s hard to pinpoint how cannabis cannabinoids will affect the endocannabinoid system. The possibilities are endless, based on the ratios of receptors in the body and cannabinoid compounds in cannabis alone.
Most people find that using cannabis helps reduce general pain, fatigue, anxiety, insomnia, depression, and mood disorders. However, you’ll need to try lots of different strains to determine which is the best combination for you.
And even when you find a strain that works, keep in mind that the effects it has on you may change, depending on your body’s unique chemistry and state of overall health.
Final Thoughts
The endocannabinoid system is a network of cells, organs, and chemical signals that influence a variety of body mechanisms, namely the nervous system, immune system, sleep, appetite, and pain response.
Research shows that impairments within the endocannabinoid system may lead to disease and unwanted symptoms.
Using marijuana is a good way to stimulate the endocannabinoid system and encourage the body to remain in homeostasis, but you may need to try a variety of marijuana strains to determine the best combination for you.
Have you noticed any of the above effects? Do you know anything about related biology? Please tell us about your experiences in the comments section below!

These out-of-this-world rocks are made by taking a nugget of marijuana and coating it with either hash oil, or shatter and then rolling it in kief. The top kief layer resembles a pollen coating and contains not only a kick of cannabis but a high level of beneficial terpenes. Moon rocks are traditionally made with Girl Scout Cookies, the strain-not the biscuits sold door-to-door, but can be made with whatever type tickles your fancy.
So, you’ve decided that moon rocks are for you and you want to give them a go? Pre-rolls may be the easiest choice since there’s no extra preparation on your part. Just light up and smoke. Nuggets are a better choice if you want more bang for your buck and have glassware or a pipe that you can smoke it with. You can find a wide variety of ready-to-go Moon Rocks Pre-rolled Blunts and Moon Rocks at
Moonrock Pre-Rolled Blunts: Each Blunt is 1.2 grams. Contains Bud rolled in CO2 honey oil before they’re rolled in kief. Each separate Moon Rock flavour is made from a different type of cannabis and premium honey oil. Coated with strain-specific high-grade Keif.
Moon Rocks: Consisting of a premium flower rolled in Co2 Honey oil and powdered with golden kief. Total: 1.1 GRAMS plus extra keif. Moonrock is easily one of the most powerful cannabis products on the planet. They have taken cannabis buds and kicked it into high gear by mixing it with oil and kief. This process leads the product to carry a 51 – 60 % THC rating.
Moon rocks aren’t as straightforward to smoke as normal flower so keep reading for some simple steps to take you out of this world.

The stigma that all pot smokers are lazy stoners simply is not true. And with legalization rates increasing all over the world, it’s time we put this theory to rest.
Although cannabis use has exploded in popularity over the past decade, many employers still test job applications for cannabis use based on the assumption that using weed in one’s free time would negatively impact their work performance.
This beautiful open space is packed with ancient soils, rich in nutrients, and showered with heavy rainfall. Take one look at the luscious green that blankets this picturesque landscape and anyone could see how perfect it is for the growth of happy flora. This diverse plant life flourishes in the hot summer months and cool fall months that follow. Cannabis is no exception and the conditions make for tall, hardy plants indoors and outdoors. The Kootenays located in British Columbia is known as the home of outdoor marijuana cultivation due to the pure mountain water, and fresh air, while boasting of having the most fertile soil on the planet.
With a record number of BC residents indulging in cannabis culture it is no surprise that it would make its way into the mainstream. Canada is known for its lax policies on marijuana but in British Columbia, this reaches new heights with 20% of the population claiming that they have recently gotten high.
Despite the recent legalization of cannabis, there are still people who view these groovy green buds as controversial, taboo drugs. This is brought about by years of misinformation, the war on drugs, and our vast cultural diversity. With more research shedding light on the many benefits, public opinion does seem to be heading in a more accepting direction as time goes on. This is hugely due to the change in rhetoric as cannabis goes from an illegal drug that will harm the youth into a highly effective medicine and health supplement.

This natural sun protectant will have a fairly low SPF without the zinc oxide so I strongly recommend adding it for full coverage and protection. First, I will take you through some of the best oils for creating your summer concoction.
Robert Gordon Wasson was the first modern man to get people interested in magic mushrooms. After 1955 he traveled to Southern Mexico to participate in a psilocybin ritual held by a local tribe. In 1957 he published the very popular article, “Seeking The Magic Mushroom” where he shares his experiences. Unfortunately, the locals ended up regretting ever inviting him into their small community. His article opened a floodgate. The area became overrun with people looking to have a similar experience
In one experiment he gave prisoners psilocybin to see if it could be an effective psychotherapy aide. The results were incredible! Six months into the treatment the subject’s recidivism rate was 40% lower.
There are many reasons why ingesting this green medicine can be beneficial over rolling up a joint to smoke.
Ingredients:
Although pre-rolls are sometimes considered the fast food of the cannabis industry, it appears that many weed users are changing their minds. Pre-roll sales are booming – and that’s an understatement.
Pre-rolls are easy to use for those who don’t know how to roll their own weed yet. They are also popular among medical cannabis patients who may not have the dexterity to roll or grind their own weed as well as high-risk patients who cannot share a joint with someone else.
compliments your mood and light up.
The back story of Santa may not be as innocent as you would think. In Siberia, where muscaria has been used for centuries, shamans used the fungi to commune with the spirit world. These Shamans would dry the mushrooms and give them as gifts on the winter solstice. On top of this, they would wear red suits with white spots to resemble the mushrooms which grew under evergreen trees. Reindeer in this region were the Shamans “spirit animals and are also known users of this magical substance. With all of these connections and the fact that the mushrooms could bring about hallucinations making it seem like the reindeer could fly, it all seems overwhelmingly likely.
Scientists used to believe that adults could no longer create new brain cells. This is normally true but magic mushrooms cause the growth of new brain cells. This has led to researching how they could positively affect people with diseases like Alzheimer’s. Not only does it create new brain cells it also connects activity that wouldn’t normally be attainable. In a study done at King’s College in London, they scanned 15 volunteers’ brains after taking a placebo and after taking psilocybin. There is strong activity in areas of the brain that are not normally connected after taking psilocybin.
We now know that this plant in its raw form is a nutritional powerhouse but it may have other long-lasting benefits to keep your body as healthy as it can be.
The delicious, green leaves of the cannabis plant can be enjoyed the same way as any other leafy greens such as spinach, kale, or Swiss chard. After washing these nutritional greens they can be added to salads, smoothies, garnish, or can be juiced or sautéed with a meal. It’s important to note that marijuana becomes intoxicated when heated to 220 degrees Fahrenheit so a kitchen thermometer is useful if you choose to cook them. The most convenient way to consume this huge amount of nutrients found in the plants is by juicing it. After juicing the raw cannabis it can be added to smoothies or mixed with other fruit juices. To preserve it just add the juice into an ice cube tray and save it for future recipes.
THC, short for tetrahydrocannabinol, is the psychoactive compound found in cannabis that creates the feeling of being “high”. It’s not only the perfect way to unwind after a long day but a natural medicine used by humans throughout the centuries. THC works by attaching itself to cannabinoid receptors in the brain, activating neurons that affect pleasure, memory, thinking, and perception. Due to the stigmatization of THC, there hasn’t been much new research but the anecdotal evidence is full of astounding accounts of how THC has drastically improved mental and physical health for people from all walks of life.
This medicinal, green herb has been proven to kill cancer cells and shrink tumors. With the incredible anti-cancer power that THC carries, you would be hard-pressed to find someone unwilling to try this natural remedy. Doctors say that THC affects cancer in 3 different ways.